Epigenetic mechanisms involve chemical and physical changes to the structure of DNA without changes in the underlying sequence. Epigenetics allows for fine-tuned control of gene expression and is the basic mechanism whereby a single human genome can give rise to over 200 different cell types in the adult organism. We are interested in the interplay between genetic and epigenetic factors, and their role in determining cell state and disease etiology. Our research involves developing statistical tools for mapping genomic and epigenomic landscapes and using this data to understand causes of human disease. The current area of focus in our group is the development of single-cell analysis methods to better understand the role that intra-tumor heterogeneity plays in cancer.