BST227

Introduction to Statistical Genetics

Course Head: Martin Aryee, PhD

Teaching Associate: Caleb Lareau

Announcements

Here, we’ll post carbon copies of annoucements also distributed on Canvas

11-Dec TA Announcements for Week of December 11
04-Dec TA Announcements for Week of December 4
26-Nov TA Announcements for Week of November 27
21-Nov Final Projects Group
13-Nov TA Annoucements week of 13 November
26-Oct Homework 1 information
25-Oct Lab and HW 1

Overview

This course will provide an introduction to statistical methods for genetic studies. The emphasis of this course is on understanding basic concepts and methods and how they are applied in the analysis of population genetic data. The course starts out with an overview of methods for identifying disease-associated variants, and then goes on to cover approaches for interpreting the role of these variants in disease. A background in genetics is not necessary. The basic concepts of human and molecular genetics relevant to the course will be covered in class.

Schedule

Class: Mon, Wed 3:45PM - 5:15PM, Kresge 202B
Section: Wed 5:30PM - 7:30PM, FXB G13

Instructor office hours: Mon 12:00PM - 1:00PM, Building 2 Room 419
TA office hours: Mon 6:10PM - 7:10PM, FXB G11

Lectures

23-Oct Introduction and overview of genetic disease
25-Oct Mendel’s Laws and genetic models for disease
30-Oct Hardy Weinberg Equilibrium and recurrence risk ratios
1-Nov An overview of linkage and association
6-Nov Introduction to GWAS
8-Nov Population Substructure
13-Nov Analysis of rare variants and non-SNP variation
15-Nov Variant calling from high-throughput sequencing data
20-Nov Estimating Heritability from Family Data and from Genome Data

Thanksgiving break

27-Nov Using the 3-dimensional organization of DNA to interpret variants
29-Nov Heritability from summary statistics & epigenetic enrichments
4-Dec Genetic association studies in cancer
6-Dec Editing DNA to interpret variants
11-Dec Epigenome-wide Association Studies (EWAS)
13-Dec Project presentations

Supplemental Reading

Supplemental reading for various lectures can be found here.

Final Project

The details for the final project and group assignments are posted here.

Presentation slides for each group are posted here.

Homeworks

Assignments are posted here
Solutions are posted here

Lab Sections

Materials for the lab exercises are posted here