Course Head: Martin Aryee, PhD
Teaching Associate: Caleb Lareau
Here, we’ll post carbon copies of annoucements also distributed on Canvas
|11-Dec||TA Announcements for Week of December 11|
|04-Dec||TA Announcements for Week of December 4|
|26-Nov||TA Announcements for Week of November 27|
|21-Nov||Final Projects Group|
|13-Nov||TA Annoucements week of 13 November|
|26-Oct||Homework 1 information|
|25-Oct||Lab and HW 1|
This course will provide an introduction to statistical methods for genetic studies. The emphasis of this course is on understanding basic concepts and methods and how they are applied in the analysis of population genetic data. The course starts out with an overview of methods for identifying disease-associated variants, and then goes on to cover approaches for interpreting the role of these variants in disease. A background in genetics is not necessary. The basic concepts of human and molecular genetics relevant to the course will be covered in class.
Class: Mon, Wed 3:45PM - 5:15PM, Kresge 202B
Section: Wed 5:30PM - 7:30PM, FXB G13
Instructor office hours: Mon 12:00PM - 1:00PM, Building 2 Room 419
TA office hours: Mon 6:10PM - 7:10PM, FXB G11
|23-Oct||Introduction and overview of genetic disease|
|25-Oct||Mendel’s Laws and genetic models for disease|
|30-Oct||Hardy Weinberg Equilibrium and recurrence risk ratios|
|1-Nov||An overview of linkage and association|
|6-Nov||Introduction to GWAS|
|13-Nov||Analysis of rare variants and non-SNP variation|
|15-Nov||Variant calling from high-throughput sequencing data|
|20-Nov||Estimating Heritability from Family Data and from Genome Data|
|27-Nov||Using the 3-dimensional organization of DNA to interpret variants|
|29-Nov||Heritability from summary statistics & epigenetic enrichments|
|4-Dec||Genetic association studies in cancer|
|6-Dec||Editing DNA to interpret variants|
|11-Dec||Epigenome-wide Association Studies (EWAS)|
Supplemental reading for various lectures can be found here.
The details for the final project and group assignments are posted here.
Presentation slides for each group are posted here.
Materials for the lab exercises are posted here